p38 MAPK及其抑制剂在子宫内膜异位症中的作用

The action of p38 MAP kinase and its inhibitors on endometriosis

子宫内膜异位症(EMs)是与炎症有关的雌激素依赖性疾病。p38丝裂原活化蛋白激酶(p38MAPK)受性激素、炎症因子等因素的激活,在细胞凋亡、增殖、炎症、应激等多种细胞反应中起着重要的作用,并直接参与子宫内膜异位症发生发展过程的调控。p38MAPK信号转导通路在性激素和炎症之间的特殊调节作用,将有助于更好地理解子宫内膜异位症错综复杂的病理假说。p38MAPK抑制剂在子宫内膜异位症的研究中发挥重要作用,且前景广阔。在信号通路水平上阻断和调控p38MAPK的表达和活性,有望成为防治子宫内膜异位症的新策略。

Endometriosis,an oestrogen-dependent disorder,is related to inflammation.p38 Mitogen activated protein kinases （p38 MAPK） can be activated by sex hormone and inflammatory factors,which plays an important role in many cellular reactions such as apoptosis,proliferation,inflammation and stresses,etc.Many studies showed that p38 MAPK was participated directly in regulating the pathogenesis of endometriosis.The special regulatory action of p38 MAPK on sex hormone and inflammation may help us to understand the intricate endometriosis pathological hypothesis.p38 MAPK inhibitors play a key role in the the study of endometriosis,and show great promise for the future.Blocking and regulating the expression of p38 MAPK on the signal transduction pathway level may hope to be a new strategy to prevent and treat endometriosis.