新见四种胃癌相关抑癌基因甲基化
摘要
抑癌基因启动子-CpG-岛甲基化是抑癌基因表达下降的一种重要修饰方式,与肿瘤的发生关系密切。胃癌的发生是多种因素累积的结果,抑癌基因甲基化与胃癌的发生可能具有重要的关系。在此综述新见4种胃癌相关抑癌基因甲基化:锌指蛋白1基因,速激酶1基因,电压依赖性钙通道α2/δ3亚基基因,X染色体连锁凋亡抑制蛋白相关因子1基因。
出处
《华西医学》
CAS
2010年第2期437-439,共3页
West China Medical Journal
参考文献10
-
1Ivanauskas A, Hoffmann J, Jonaitis LV, et al. Distinct TPEF/ HPP1 gene methylation patterns in gastric cancer indicate a field effect in gastric carcinogenesis [J]. Dig Liver Dis,2008,40(12) : 920-926.
-
2Roy M, Pear WS, Aster JC. The multifaceted role of Notch in cancer[J]. Curr Opin Genet Dev, 2007,17(1) : 52-59.
-
3Zhao H, Ayrault O, Zindy F, etal. Post-transcriptional downregulation of Atohl/Mathl by bone morphogenic proteins suppresses medulloblastoma development[J]. Genes Dev, 2008, 22 (6) :722-727.
-
4Liang JW, Hong CJ, Xian W, et al. ZIC1 is downregulated through promoter hypermethylation in gastric cancer [J]. Biochem Biophys Res Commun, 2009,379 (4) : 959-963.
-
5Jin Z, Olaru A, Yang J, et al. Hypermethylation of tachykinin-1 is a potential biomarker in human esophageal cancer[J]. Clin Cancer Res, 2007,13(21) : 6293.
-
6Mori Y, Cai K, Cheng Y, et al. A genome-wide search identifies epigenetic silencing of somatostatin, tachykinin-1, and 5 other genes in colon cancer[J]. Gastroenterology,2006,131(3): 797-808.
-
7Ernst A, Suhr J, Kohrle J, et al. Detection of stable N-terminal protachykinin A immunoreactivity in human plasma and cerebrospinal fluid[J]. Peptides,2008,29(7) : 1201-1206.
-
8David S, Kan T, Cheng Y, et al. Aberrant silencing of the endocrine peptide gene tachykinin-1 in gastric cancer [J]. Biochem Biophys Res Commun, 2009,378 (3) : 605- 609.
-
9Wanajo A, Sasaki A, Nagasaki H, etal. Methylation of the calcium channel-related gene, CACNA2D3, is frequent and a poor prognostic factor in gastric cancer [J]. Gastroenterology, 2008, 135(2) :580-590.
-
10曾晖,黄越前,周峰,纪华英,李博璋,梁庆辉,邹冰.人胃癌细胞株和胃癌组织中XAF1基因表达缺失机制的研究[J].胃肠病学,2008,13(7):393-397. 被引量：1
二级参考文献14
-
1Zou B, Chim CS, Zeng H, et al. Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. Gastroenterology, 2006, 131 (6): 1835-1843.
-
2Green DR, Evan GI. A matter of life and death. Cancer Cell, 2002, 1 (1): 19-30.
-
3Igney FH, Krammer PH. Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer, 2002, 2 (4): 277-288.
-
4Zimmermann KC, Bonzon C, Green DR. The machinery of programmed cell death. Pharmacol Ther, 2001, 92 (1): 57-70.
-
5Salvesen GS. Caspases: opening the boxes and interpreting the arrows. Cell Death Differ, 2002, 9 (1): 3-5.
-
6Deveraux QL, Reed JC. IAP family proteins - suppressors of apoptosis. Genes Dev, 1999, 13 (3): 239-252.
-
7Deveraux QL, Takahashi R, Salvesen GS, et al. X-linked IAP is a direct inhibitor of cell-death proteases. Nature, 1997, 388 (6639): 300-304.
-
8Roy N, Deveraux QL, Takahashi R, et al. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J, 1997, 16 (23): 6914-6925.
-
9LaCasse EC, Baird S, Korneluk RG, et al. The inhibitors of apoptosis (lAPs) and their emerging role in cancer. Oncogene, 1998, 17 (25): 3247-3259.
-
10Salvesen GS, Duckett CS. IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol, 2002, 3 (6): 401-410.
-
1朱立宁,徐岷,张尤历.DNA甲基化与胰腺癌的研究进展[J].国际消化病杂志,2012,32(2):104-106. 被引量：1
-
2王培培,张翠英.hMLH1、DAPK基因启动子区甲基化与肺癌耐药的相关性[J].肿瘤研究与临床,2016,28(3):207-209. 被引量：1
-
3吴春利,耿小平,朱立新.DNA甲基化与胆囊癌[J].国际外科学杂志,2008,35(8):568-571.
-
4舒健,陈勇兵,李森.Ad/F35-XAF1对非小细胞肺癌细胞增殖和凋亡的影响[J].江苏医药,2014,40(15):1739-1741.
-
5黄佳,姚玮艳,朱黎明,曹海霞,章永平.XAF1基因对胰腺癌细胞SW1990增殖和凋亡的影响[J].上海交通大学学报（医学版）,2009,29(4):378-380. 被引量：3
-
6朱传东,王礼学,郭晶晶,耿杰,徐瀚峰,张全安,郑勤.XAF1基因对顺铂诱导肺腺癌A549细胞凋亡作用的研究[J].中华肿瘤防治杂志,2013,20(19):1499-1502. 被引量：1
-
7曾晖,黄越前,周峰,纪华英,李博璋,梁庆辉,邹冰.人胃癌细胞株和胃癌组织中XAF1基因表达缺失机制的研究[J].胃肠病学,2008,13(7):393-397. 被引量：1
-
8曾颖,康晓静.DNA甲基化与皮肤肿瘤的研究进展[J].国际皮肤性病学杂志,2015,41(4):253-255. 被引量：2
-
9王蒙.哺乳动物DNA甲基化与基因表达调控[J].中国实用医药,2009,4(32):218-219.
-
10刘天会,刘秉华.半胱天冬酶的磷酸化[J].国外医学（遗传学分册）,2005,28(6):339-341.
