老老年患者颈动脉中层厚度的相关危险因素分析

The Correlation Risk Factors Analysis of Carotid Arterial Intima-Media Thickness in Elderly Age Patients

目的:探讨老老年患者颈动脉中层厚度(IMT)及其相关危险因素的关系,为老老年患者心脑血管疾病的预防及治疗提供临床参考。方法:根据年龄将139例老老年患者纳入分析,有血糖、血压、血脂代谢紊乱的123例作为观察组,无血糖、血压、血脂代谢紊乱的16例作为对照组,分别进行颈动脉超声检查、动态血压监测、糖化血红蛋白及血脂等生化指标检查,并结合临床资料进行分析。结果:老老年患者均无一例外地存在着IMT增厚,在相同的年龄情况下,吸烟史、血脂紊乱、糖调节异常、血管炎症反应与IMT的增厚呈正相关,各组未显示出统计学差异,IMT的发生发展与年龄、性别、吸烟史、血糖、血压控制水平及血脂紊乱等因素在两组对照中均未显示出统计学差异,多因素Logistic回归分析,显示年龄、吸烟史及病程为危险因素(OR为0.500～1.196)。结论:老老年患者均不同程度地存在着IMT增厚,其中增龄是其最主要的危险因素,但是对合并有血糖、血压、血脂代谢紊乱的老老年患者也应该积极重视对各种危险因素的筛选和干预,特别在疾病发生发展的早期可能对延缓病变的进展和减少心脑血管事件有一定意义,可是其用药的安全性在该类患者就显得尤为重要。

Objective： To investigate the relationship of carotid arterial intima-media thickness in elderly age patients and its risk factors analysis,and provide clinical reference in prevention and treatment of cardiovascular and cerebrovascular disease.Methods： According to years of elderly age enrolled into analysis for 139 instance,which observation group had 123 example blood sugar,blood pressure and blood-fat with metabolic disorder,neither control group had 16 example,then carry out carotid ultrasonic inspection,ambulatory blood pressure,glycosylated hemoglobin and blood-fat biochemical indicator etc,and analysis combination clinical data.Results： Elderly age patients all have carotid intima-media thickness,under age no differential circumstances,smoking,blood-fat disorder,control blood sugar level and inflammatory reaction in blood vessel all spur IMT increasing,no statistic difference,the same result in IMT＇s take place and development process,multiple factor Logistic regression analysis shows that smoking,ages and course of disease are risk factors.Conclusion： Elderly age patients all have carotid arterial intima-media thickness,among the total ageing is its overriding risk factors,however elderly age patients combine blood sugar,blood pressure and blood-fat with metabolic disorder should to screen and intervention think highly of multi-risk factors,particular in nonage there is necessarily significance possible to postpone advancement pathological changes and reduce cardiovascular and cerebrovascular disease event,it is appeared very important in this kind of patients about pharmacal security.