我院67例药品不良反应报告分析

Adverse Drug Reactions in Our Hospital:A Retrospective Analysis of 67 Cases

目的:了解我院药品不良反应(ADR)发生的特点。方法:对我院2006年1月至2009年8月收集到的67例ADR报告进行回顾性统计分析。结果:我院报告ADR例数最多的部门为新生儿,有51例(76.12%);0～28 d年龄段患儿ADR发生率较高(52.23%),且男性高于女性;静脉给药方式是导致ADR的主要因素(97.01%);ADR发生率最高的为抗感染药(80.56%),其中绝大多数是由头孢菌素类和青霉素类引发;临床表现以皮肤及其附件损害最为常见(88.41%)。结论:儿童用药更应该加强ADR的监测,提高ADR报告的质量,合理、规范使用药物,尤其是抗菌药物,以减少或避免ADR的发生。

Objective： To probe into the characteristics of adverse drug reactions（ADR） occurred in our hospital.Methods： Sixty-seven ADR cases collected from Jan.2006 to Jul.2009 in our hospital were analyzed retrospectively.Results： Of the total 67 ADR cases,51（76.12%） were collected from pharmacy department;52.23% occurred in patients aged from 0 to 28 days,with males showing higher proportion than females;97.01% were induced intravenously,80.56% were induced by anti-infective druss,of which,cephalosprins and benzylpenicillin took the lead.88.41% of the ADR manifested as lesion of skin and its appendants.Conclusion： ADR monitoring should be strengthened in clinic;furthermore,the quality of ADR reporting should be improved and the use of drugs should be rationally in a standard way so as to lessen or avoid the occurrence of ADR.