摘要
目的:探讨超短波对兔实验性膝关节骨性关节炎自由基代谢影响,为临床超短波的应用提供理论依据。方法:将45只日本大耳白兔随机分出10只为正常组、余35只行右后肢膝关节伸直位固定6周的方法造模。6周后随机抽取其中5只行造模结果检测。确定造模成功后,将余下30只动物随机分为空白对照组、布洛芬治疗组、超短波治疗组,每组10只。分别给予相应干预,在治疗给药30d后测定兔血清超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)的含量。结果:超短波治疗组同空白对照组、布洛芬治疗组比较血清中SOD显著升高,NO、MDA显著降低(P<0.01);布洛芬治疗组同空白对照组比较各数值无显著性差异。结论:超短波治疗通过提高血清SOD活性,降低NO、MDA含量,从而达到保护关节软骨,防治膝关节骨性关节炎的目的。
Objective：To investigate the influence of ultrashort-wave therapy on the metabolism of free radicals so as to explore the mechanism of ultrashort-wave therapy in treatment of knee osteoarthritis（OA）.Methods：Experimental animals were randomly divided into 4 groups,with 10 cases as normal group.Except those in the normal control group,rabbit models of knee OA were established by prolonged fixation of the knee joint in extension for 6 weeks.The treatment was as follows ：nothing in model group and normal control group,those in the brufen group were treated with gastric perfusion receiving 10ml 0.031g/mL ibuprofen suspension daily,The animals in ultrashort-wave therapy group were treated with ultrashort-wave for 20min,once a day for 30 days.the levels of nitric oxide（NO）superoxide dismutase（SOD）and malondialdehyde（MDA）in serum were observed respectively in each group in the 30th day.Results：The level of NO in ultrashort-wave group was lower than that in brufen group and model group（P0.01）,with the SOD activity obviously higher and content of MDA lower than those in brufen group and model group（P0.01）.There was no significant difference between brufen group and model group（P0.05）.Conclusion：ultrashort-wave therapy could effectively delay the degeneration of articular cartilage and promote cartilage repair through inhibiting the generation of NO,increasing SOD activity and decreasing MDA content.
出处
《陕西医学杂志》
CAS
2010年第5期536-538,546,共4页
Shaanxi Medical Journal
