长托宁治疗急性肺损伤33例疗效观察

Clinical study on treatment of acute lung injury with penequinine hydrochloride

目的:探讨长托宁(盐酸戊乙奎醚,PQN)治疗急性肺损伤(ALI)患者的临床疗效。方法:将56例各种原因引起的急性肺损伤患者随机分为PQN组(长托宁+标准治疗)和标准(ST)组(仅标准治疗);比较两组治疗前后2h、24h的呼吸频率、心率、动脉血气分析、肺损伤评分(LIS)和急性生理和慢性健康状况评分(APACHE)。2比较两组病死率及住院时间。结果:1PQN组治疗后2h、24hPO2/FiO2和pH值与治疗前比较明显改善,心率和呼吸频率减慢,APACHE评分和肺损伤评分显著下降。ST组除了24hPO2/FiO2与治疗前比较差异有性显著外,余指标与治疗前比较均无显著性差异。PQN组病死率低于ST组,平均住院天数短于标准组。结论:长托宁治疗ALI能迅速改善患者的气体交换和生命体征,提高救治成功率,缩短住院时间。

Objective：To evaluate the clinical effect of penequinine hydrochlordie（PQN）in acute lung injury（ALI）.Methods：56 patients with ALI caused by all kinds of diseases were divided at random into standard medical therapy alone（ST group）and standard medical therapy plus PQN（PQN group）.The respiratory rate,heart rate,arterial blood gas,lung injury score（LIS）and acute physiology and chronic health evaluation II（APACHE II）at admission on 2 hours,24 hours were compared.The mortality and the length of hospital stay of two groups were study.Results：①In PQN group,there were significant improvement in PaO2/FiO2,pH,RR and HR on the 2 hours,24 hours after therapy.In ST group,there were no obvious differences in above-mentioned parameters exclusive of 24h PaO2/FiO2.②The mortality was markedly lower in the PQN group than in the ST group.The length of hospital stay was significantly shorter in the PQN group than in the ST group.Conclusion：PQN can improve rapidly gas exchange and vital signs of patients with ALI;it increase the success rate of treatment,and decrease the length of hospital stay.PQN is an important respiratory support method for ALI induced by many reason.