血脂异常对2型糖尿病患者胰岛素分泌功能的影响

Effects of dyslipidemia on insulin secretion function in patients with type 2 diabetes mellitus

目的探讨血脂异常对T2DM患者胰岛素分泌功能的影响。方法初诊的T2DM患者100例,未经调脂和降糖治疗,根据血脂水平分为血脂正常组(A组)、单纯TG升高组(B组)和混合血脂升高组(C组),以30名健康者作对照(NC组),采用HOMA-β评价β细胞分泌功能。结果与NC组比较,A、B、C三组的HOMA-β均明显降低(P<0.01);与A组比较,B、C组的HOMA-β降低(P<0.01);B、C组之间比较差异无统计学意义(P>0.05)。HOMA-β相关因素同归分析显示TG为独立影响因素。结论 TG升高可降低T2DM患者的胰岛素分泌功能,TC没有独立于TG以外的降低胰岛素分泌功能的作用。

Objective To investigate the effects of dyslipidemia on insulin secretion function in patients with T2DM. Methods 100 newly diagnosed TgDM patients without lipid-lowering and anti- hyperglycemic therapies were divided into 3 groups： normal lipids （group A）, single high triglyceride （group B） and high trigtyceride and high total cholesterol or high LDL-cholesterol with or without low HDL-cholesterol （group C）. The 30 healthy subjects were as normal control group （ NC group）. HOMA- β was Used to evaluate the secretion function of islet β cells. Results Compared with NC group, group A, B and C had a signficantly lower HOMA-β （P〈0.01）. The group B and C had a significantly lower HOMA-β than did group A （both P〈0.01）, but no significant differences in the HOMA-β between group B and C. The multiple linear regression analysis showed that TG was an independent influencing factor for HOMA-β. Conclusions High triglyceride reduces insulin secretion function but cholesterol abnormalities alone do not reduce insulin secretion function in TgDM.