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T细胞特异性转录因子T—bet、GATA3调控子痫前期辅助性T淋巴细胞1型免疫漂移的研究 被引量：3

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摘要 子痈前期是产科常见且严重的妊娠并发症，是导致围产儿及孕产妇死亡的重要原因^[1]。研究发现辅助性T淋巴细胞1和2（Thelper1／Thelper2，Th1／Th2）免疫状态向Th1漂移是子痢前期发病的重要免疫机制^[1-4]，因此研究子痫前期产生Th1型漂移的免疫调控机制有助于进一步了解其病理生理机制，目前国内外尚未见相关研究报道。
作者 周建军 胡娅莉 王志群 郑明明 赵霞 凌静娴 顾香芳
机构地区 南京大学医学院附属鼓楼医院妇产科
出处 《中华围产医学杂志》 CAS 2010年第3期224-226,共3页 Chinese Journal of Perinatal Medicine
基金 南京大学医学院附属鼓楼医院青年科研启动基金（14）
关键词 辅助性T淋巴细胞1 免疫调控机制 免疫漂移 子痫前期 特异性转录因子 GATA3 T细胞 病理生理机制
分类号 R714.7 [医药卫生—妇产科学]
  • 相关文献

参考文献11

  • 1Sibai B,Dekker G,Kupfermine M.Pre-eelampsia.Lancet,2005,365:785-799.
  • 2Redman CW,Sargent IL.Latest advances in understanding preeclampsia.Science,2005,308:1592-1594.
  • 3Challis JR,Lockwood CJ,Myatt L,et al.Inflammation and pregnancy.Reprod Sci,2009,16:206-215.
  • 4周建军,胡娅莉,郝莎,侯亚义.子痫前期患者母-胎界面子宫自然杀伤细胞免疫表型及辅助性T淋巴细胞1、2免疫状态的研究[J].中华妇产科杂志,2007,42(4):244-248. 被引量：7
  • 5Hatton RD,Weaver CT.Immunology.T-bet or Not T-bet.Science,2003,302:993-994.
  • 6Li-Weber ML,Krammer PH.Regulation of IL-4 gene expression by T cells and therapeutic perspectives.Nat Rev Immunol,2003,3:534-543.
  • 7Schmittgen TD,Livak KJ.Analyzing real-time PCR data by the comparative C(T)method.Nat Protoe,2008,3:1101-1108.
  • 8Livak KJ,Schmittgen TD.Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T))Method.Methods,2001,25:402-408.
  • 9Szabo SJ,Kim ST,Costa GL,et al.A novel transcription factor,T-bet,directs Th1 lineage commitment.Cell,2000,100:655-659.
  • 10Finotto S,Neurath MF,Glickman JN,et al.Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet.Science,2002,295:336-338.

二级参考文献22

  • 1林其德,邱丽华.原因不明复发性流产与母-胎界面免疫耐受[J].中华妇产科杂志,2006,41(3):145-147. 被引量：26
  • 2周建军,胡娅莉,侯亚义,王志群,郝莎,戴毅敏,李洁.足月妊娠母胎界面与系统免疫中NK细胞表型和T细胞变化的研究[J].中华围产医学杂志,2006,9(5):309-314. 被引量：9
  • 3Eidukaite A,Siaury A,Tamosiunas V.Differential expression of KIR/NKAT2 and CD94 molecules on decidual and peripheral blood CD56^bright and CD56^dim natural killer cellsubsets.Fertil Steril,2004,81:863-868.
  • 4Ho HN,Chao KH,Chen HF,et al.Distribution of Th1 and Th2 cell populations in human peripheral and decidual T cells from normal and anembryonic pregnancies.Fertil Steril,2001,76:797-803.
  • 5Moffett-King A.Natural killer cells and pregnancy.Nat Rev Immunol,2002,2:656-663.
  • 6Bulmer JN,Lash GE.Human uterine natural killer cells:a reappraisal.Mol Immunol,2005,42:511-521.
  • 7Sindram-Trujillo AP,Scherjon SA,van Hulst-van Miert PP,et al.Comparison of decidual leukocytes following spontaneous vaginal delivery and elective cesarean section in uncomplicated human term pregnancy.J Reprod Immunol,2004,62:125-137.
  • 8Sindram-Trujillo AP,Scherjon SA,van Hulst-van Miert PP,et al.Differential distribution of NK cells in decidua basalis compared with decidua parietalis after uncomplicated human term pregnancy.Hum Immunol,2003,64:921-929.
  • 9Zingoni A,Palmieri G,Morrone S,et al.CD69-triggered ERK activation and functions are negatively regulated by CD94/NKG2-A inhibitory receptor.Eur J Immunol,2000,30:644-651.
  • 10Saito S,Sakai M.Th1/Th2 balance in preeclampsia.J Reprod Immunol,2003,59:161-173.

共引文献14

同被引文献36

  • 1Jinfang Zhu Hidehiro Yamane Javier Cote-Sierra Liying Guo William E Paul.GATA-3 promotes Th2 responses through three different mechanisms： induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Thl cell-specific factors[J].Cell Research,2006,16(1):3-10. 被引量：49
  • 2Gauster M,Moser G,Orendi K,et al.Factors involved in regulating trophoblast fusion: potential role in the development of preeclampsia.Placenta,2009,30:S49-S54.
  • 3Huppertz B,Kingdom JC.Apoptosis in the trophoblast-role of apoptosis in placental morphogenesis. J Soc Gynecol Investig,2004,11:353-362.
  • 4Nagamatsu T,Schust DJ.The immunomodulatory roles of macrophages at the maternal-fetal interface. Reprod Sci,2010,17:209-218.
  • 5Harris LK.Review:Trophoblast-vascular cell interactions in early pregnancy:how to remodel a vessel.Placenta,2010,31:S93-S98.
  • 6Knofler M.Critical growth factors and signalling pathways controlling human trophoblast invasion. Int J Dev Biol,2010,54:269-280.
  • 7Chamley LW, Chen Q, Ding J, et al. Trophoblast deportation:just a waste disposal system or antigen sharing? J Reprod Immunol,2011,88:99-105.
  • 8Hutchinson ES, Brownbill P,Jones NW, et al. Uteroplacental haemodynamics in the pathogenesis of preeclampsia.Placenta,2009,30:634-641.
  • 9GullerS. Role of the syncytium in placenta-mediated complications of preeclampsia.Thromb Res,2009,124:389-392.
  • 10GoswamiD, Tannetta DS, Magee LA, et al. Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia,but not normotensive intrauterine growth restriction.Placenta,2006,27:56-61.

引证文献3

二级引证文献3

中华围产医学杂志
2010年 第3期

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