舍曲林联合舒眠胶囊治疗抑郁症睡眠障碍的疗效观察

Efficacy of Sertraline Combine with Shumian Capsule in the Depression of Dyssomnia

目的:比较单用舍曲林与联合舒眠胶囊治疗抑郁症睡眠障碍的疗效和安全性。方法:将86例抑郁症患者随机分为单用组和联用组。治疗8周后采用汉密尔顿抑郁量表(HAMD)、匹兹堡睡眠质量指数量表(PSQI)评定疗效,不良反应量表(TESS)评价药品不良反应(ADR)。结果:治疗8周后,联用组有效率(88.2%)显著高于单用组(85.7%)(P<0.05);联用组治疗后HAMD及PSQI评分显著低于单用组(P<0.01);治疗后2组ADR发生率比较,差异无统计学意义(P>0.05)。结论:舍曲林联合舒眠胶囊治疗抑郁症睡眠障碍优于单用舍曲林,且不增加ADR的发生率。

OBJECTIVE：To observe the efficacy and safety of sertraline combined with Shumian capsule for depression of dyssomnia.METHODS：86 patients with depression were randomly assigned to receive sertraline alone（single group） or in combination with Shumian capsule（combined group） for 8 weeks.Clinical effectiveness was evaluated using HAMD and PSQI,and TESS was used to assess the adverse effects.RESULTS：After treatment for 8 weeks,the total effective rate was 88.2% for combined group and 85.7% for single group（P0.05）.The HAMD and PSQI scores in combined group are lower than in single group（P0.01）,and the difference in adverse drug reactions was not significant in 2 groups.CONCLUSION：Sertraline combined with Shumian Capsule showed better efficacy for the depression of dyssomnia yet without increasing adverse dffdcts as compared with Sertraline alone.