某院阿米卡星临床用药分析

Analysis Clinical Drug Use of Amikacin in a Hosiptal

目的:促进阿米卡星临床合理应用。方法:采用回顾性调查方法,对某院自2006年4月～2010年2月使用阿米卡星并进行血药浓度测定的30例住院患者的临床资料进行统计、分析,包括基础疾病、病原学培养及药敏试验结果、阿米卡星用法、用量、血药浓度测定时间、临床疗效、不良反应情况等。结果:患者使用阿米卡星后临床有效率为55.2%;住院患者使用阿米卡星的药量偏低,血药浓度测定值与参考值相比也偏低;使用阿米卡星治疗后未见不良反应发生。结论:应适当提高阿米卡星用量比例并严密监测阿米卡星的血药浓度,实现个体化给药,以提高临床用药的有效性与安全性。

OBJECTIVE：To reference clinical utilization of amikacin of a hospital.METHODS：By retrospective survey,the clinical information of 30 inpatients who were treated with amikacin and received plasma concentration monitoring from Apr.2006 to Feb.2010 were analyzed statistically in respect of primary disease,results of pathogen culture and drug sensitivity test,dosages and usage,plasma concentration,clinical efficacy,adverse drug reactions,etc.RESULTS：Clinical response rate was 55.2% and dosage of amikacin was small as well as measured value and reference value of plasma concentration.No adverse drug reaction was observed.CONCLUSION：The proportion of amikacin should be increased and plasma concentration monitoring of amikacin should be strengthened.Individual regimen is realized to improve effectiveness and safety of drug use.