国产司帕沙星治疗急性细菌感染的Meta分析

Meta-analysis of Domestic Sparfloxacin for Acute Bacterial Infections with Oral Administration

目的:评价国产司帕沙星口服治疗急性细菌感染的临床疗效和安全性。方法:计算机检索国内1993～2009年有关国产司帕沙星治疗急性细菌感染的文献,并逐个进行质量评价和资料提取,用RevMan4.2.2软件进行Meta分析。结果:共有10项随机对照试验符合纳入标准。试验组使用司帕沙星,对照组使用其它氟喹诺酮类药物。试验组和对照组的临床痊愈率、临床有效率、细菌清除率和安全性比较均具有同质性。2组的临床痊愈率、临床有效率和细菌清除率的合并效应量的估计比较,差异有统计学意义(P<0.05),而安全性比较差异无统计学意义(P>0.05)。结论:现有的临床研究证据表明,国产司帕沙星口服治疗急性细菌感染的临床疗效较好,不良反应的发生率较低。

OBJECTIVE：To assess the clinical efficacy and safety of domestic sparfloxacin for acute bacterial infections.METHODS：Domestic literatures about sparfloxacin for acute bacterial infections were retrieved by computer and their quality was evaluated to extract data（1993～2009）.RevMan 4.2.2 software was used for Meta-analysis.RESULTS：A total of 10 RCT were enrolled.The comparisons of 2 groups were homogeneous in terms of clinical cure rate,clinical response rate,bacterial clearance rate and safety.There was statistical significance in comparison of combined effect variable between 2 groups in respect of cure rate,response rate and bacterial clearance rate（P0.05）.But the comparison of clinical safety had no statistical significance（P0.05）.CONCLUSION：The currently available evidence shows that clinical efficacy of domestic sparfloxacin for acute bacterial infections is better and incidence of ADR was lower.