冠状动脉闭塞后冠脉侧支循环建立的实验研究

Experiment Study of Collateral Circulation in Coronary Artery Occlusion

目的：观察犬冠状动脉左前降支（ＬＡＤ）阻断后，冠脉侧支血管建立的时间及表现，探讨侧支血管建立对左室功能的影响。材料和方法：杂种犬８条，开胸结扎ＬＡＤ，在结扎ＬＡＤ后１天～１年内定期行冠脉和左室造影。结果：结扎ＬＡＤ后１周，造影开始显示侧支血管建立；结扎ＬＡＤ后１～３个月，皆可见程度不等的侧支血管建立，左室功能明显改善。结论：犬冠脉有丰富的侧支血管；侧支血管的建立，有助于左室收缩功能的恢复。

Purpose:To observe the collateral estabishment after coronary occlusion, and evaluate the function of collateral circulation to left ventricular.Materials and Methods:Eight canine hearts with myocardial infarction induced by left anterior descending(LAD)ligation were made,left ventricular and coronary angiography followed one day to one year after ligation LAD. Results:A few collateral blood vessels viewed by coronary angiography were begun establishment in one week after ligation LAD.One to three months after ligation LAD,collateral circulation were establishment in variety degree. Conclusion:Coronary artery of canine have a large number of collateral blood vessels; Establishment of collateral circulation is benefit to recovery of function of left ventricular.