舍曲林与氯米帕明治疗强迫症对照分析

目的:比较舍曲林与氯米帕明治疗强迫症的临床疗效和不良反应。方法:以舍曲林与氯米帕明治疗强迫症各45例,疗程8周。应用Yale-Brown强迫症量表(Y-BOCS)、汉密尔顿抑郁量表(HAMD)及汉密尔顿焦虑量表(HAMA)评定疗效,采用副反应量表(TESS)评定不良反应。结果:舍曲林与氯米帕明治疗后Y-BOCS、HAMD、HAMA分值均显著下降,两组间差异无显著性。舍曲林组不良反应明显少于氯米帕明组。结论:舍曲林治疗强迫症疗效与氯米帕明相仿,不良反应较轻。

Objeetive：qb compare the efficacy and side effects of Sertraline and clomipramine in the treatment of obsessive -compulsive analysis. Methods： Ninety patients with obsessive - compulsive analysis were randomly assigned into Sertraline group and elomipramine group for eight weeks. Efficacy were assessed with Yale - Blown obsessive - compulsive scale （ Y - BOCS ）, Hamilton depressive scale （HAMD）and Hamilton anxiety scale （ HAMA ）. The side effects were assessed by TESS. Results：There was no significant difference in efficacy between Sertraline and clomipramine. The side effects of Sertraline were less than clomipramine significantly. Conclusion： Sertraline is an effective and safe drug in the treatment of obsessive - compulsive analysis.