摘要
目的探讨Ｂａｘ基因产物在人非小细胞肺癌中的表达水平与肺癌病理生理特征之间的关系。方法应用免疫组织化学法检测１３７例人非小细胞肺癌组织中Ｂａｘ基因产物的表达。结果肺癌组织Ｂａｘ基因产物的表达水平（５７．９５％）明显低于癌旁肺组织和正常肺组织（Ｐ＜０．０１），而正常肺组织与癌旁肺组织间无差异（Ｐ＞０．０５）。转移癌组织Ｂａｘ表达水平明显低于原发癌组织（Ｐ＜０．０５），但Ｂａｘ表达水平与肺癌组织学类型及细胞分化程度无明显关系（Ｐ＞０．０５）。结论Ｂａｘ基因可能参与调控肺癌发生。
Objective To explore the relationship between the expression of Bax gene and pathophysiological features of human non small cell lung carcinoma. Methods Expressional level of Bax gene products was detected in 137 human non small cell lung carcinoma by immunohistochemistry, labelled streptravidin biotin method. Results The expressional level of Bax products in cancer samples was significantly lower than that in normal lung tissues and normal tissues adjacent to cancer ( P<0.01 ). But no significant difference was observed between the normal lung tissues and normal tissues adjacent to cancer ( P>0.05 ). The expressional level of Bax gene in metastatic tumor tissues was also significantly lower than that in primary tumor ( P<0.01) . There were no significant difference among the groups of different histoclassification and different differentiation of the cancer ( P>0.05) . Conclusion The results suggest that Bax gene may be involved in the oncogenesis, development, and metastasis of lung cancer.
出处
《中国胸心血管外科临床杂志》
CAS
1999年第1期18-20,共3页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
基金
国家自然科学基金
