2型糖尿病病人微量白蛋白尿的危险因素初探

A preliminary study on the risk factors for microalbuminuria in type 2 diabetes mellitus

目的研究2型糖尿病病人微量白蛋白尿的危险因素。方法对93例伴或不伴高血压的2型糖尿病病入进行动态血压监测，同时测定尿白蛋白排泄率、血糖、血脂等，分析其相互关系，以是否有微量白蛋白尿为因变量，拟合Logistic回归。结果血压昼夜节律异常和血压水平增高是2型糖尿病病人微量白蛋白尿发生的主要危险因素，血清甘油三酯水平升高、体重指数的增加也有增加微量白蛋白尿发生的趋势。结论长期血糖、血压、血脂控制不良将导致发生2型糖尿病病人微量白蛋白尿。

Objective To study the risk factors for microalbuminuria in type 2 diabetes mellitus. Methods Theassociations of AER (by RIA) with ambulatpry blood pressure and circadian rhythm of blood pressure (using anambulatory equipment, Accutracker-Ⅱ, Suntech ), plasma glucose (by glucose oxidase method ), HbA1c (bychromatography), serum TCh, Tg, HDL-C (by biochemical autoanalyzer) and the clinical features were studied in 93cases of type 2 diabetes mellitus patients with and without hypertension. The logistic regression analysis was used withthe microalbuminuria as the dependent variable. Results Abnormal circadian rhythm of blood pressure and increasedmean 24 hours blood pressure were main risk factors for microalbuminuria in type 2 diabetes mellitus. The increasedserum TG levels and BMI were also risk factors for microalbuminuria in type 2 diabetes mellitus.