摘要
目的为掌握我省脊髓灰质炎（脊灰）病毒型内抗原特征。方法应用脊灰单克隆抗体（ＭｃＡｂ）中和法进行型内抗原分析。结果湖南省１９８９～１９９１年有１０个地（市）为脊灰Ⅰ型野病毒传播，根据对ＭｃＡｂ反应的不同可分为４个类别，以ＰＩ—１最多，占７７．２７％（１７／２２），抗原性质属类强毒株。结论Ｐ１—１型为我省脊灰流行的主要型别，脊灰Ⅱ、Ⅲ型均为疫苗相关株病毒。方法能从抗原表位水平分析研究毒株的性质，鉴别疫苗株和野毒株，具有敏感特异。
Objective To grasp the characteristics of antigen of the subdivided polio virus in
Hunan province. Methods The neutralization method of monocolonal antibody(McAb) was
undertaken to analyse the subdivided virus antigens. Results The polio I wild virus was
transmitted in 10 prefectures during 1989～1991. According to the differences in the reaction to
monocolonal antibody, it could be classified into 4 types( subdivisions) among which PI-1 was
the most with the rate of 77.2%(17/22). Conclusion Its antigenic character belonged to
subdominant virus strain, which was the main epidemic type of polio in our province. Polio II
was vaccine related virus strain. This method with the characteristics of specificity and
simplicity can study the nature of the virus based on the epitype,and can type the vaccine virus
related strain and wild virus strain. [
出处
《实用预防医学》
CAS
1999年第1期17-19,共3页
Practical Preventive Medicine
