喹硫平与奥氮平合并舍曲林治疗难治性抑郁症的对照研究

Comparative Study of Quetiapine or Olanzapin with Sertraline in the Treatment of Refractory Depression

目的探讨喹硫平与奥氮平合并舍曲林治疗难治性抑郁症的疗效与副反应。方法将78例难治性抑郁症分为喹硫平组(39例)和奥氮平组(39例),两组患者同时服用舍曲林,观察8周。于治疗前和治疗1、2、4、6及8周末采用汉密尔顿抑郁量表(HAMD-17)评定疗效,用副反应量表(TESS)评定不良反应。结果喹硫平组显效率为69.2%,奥氮平组为66.7%,均有显著疗效,均从第2周末即显示出较好的疗效,显效率的差别两组无显著统计学意义(χ2=0.0020,P>0.05)。喹硫平组无体重增加10%者,奥氮平组体重增加10%者有4例,差异有显著统计学意义(χ2=4.216,P<0.05)。结论喹硫平或奥氮平合并舍曲林治疗不伴精神病性症状的难治性抑郁症疗效好且起效快,但喹硫平不良反应少。

Objective To explore the efficacy and safety of Quetiapine and Olanzapin with Sertraline in treating refractory depression. Methods Eighty patients with refractory depression were divided into Quetiapine group（n=39）and Olanzapin group （n = 39） with basic treatment of Sertraline and followed for 8 weeks. Hamilton depressive scale （HAMD- 17） and treatment emergent symptom scale（TESS） were used to evaluate the efficacy and side effects at the point of week 1 ,weeks 2,weeks 4 ,weeks 6 and weeks 8. Results The response rate of Quetiapine group was 69.2 % and that of Olanzapin group was 66.7 %. There was no significant difference between the two groups （X^2=0. 0020,P〉0.05）. Quetiapine group and Olanzapin group showed better efficacy. The body weight increase of Quetiapine group was nought and that of Olanzapin group was 10.27%. There was significant difference between the two groups （X^2=4. 216, P〈0.05）. Conclusion Sertraline with Quetiapine or Olanzapin in treating depression without psychotic symptoms has better efficacy. Quetiapine has less side effects compared with Olanzapin.