血管紧张素转化酶基因多态性与终未期肾衰

ANGIOTENSION CONVERTING ENZYME GENE POLYMORPHISM IN PATIENTS WITH ENDSTAGE RENAL FAILURE

目的阐明血管紧张素转化酶（ACE）基因多态性及循环中ACE水平不同在肾脏疾病进展中的意义。方法对50名终末期肾功能衰竭（ESRF）患者和60名正常人ACE基因多态性进行分析。结果ACE基因在ESRF组和正常人组杂合子型（DI）和缺失型（DD）明显高于正常人，而插入型（Ⅱ）的发生率ESRF明显低于正常人。结论ACE基因多态性与肾衰的发展及肾小球硬化的发生有一定联系，ACE基因多态性的分析，可望成为判断肾脏疾病患者预后的一个新的筛查指标。

To evaluate the role of angiotension convertingenzyme (ACE ) gene polyrnorphism in the progression of renal diseases. Method ACE gene polymorphism was analyzed in 50 patients with end stagerenal failure (ESRF) and 60 normal control. Result The frequences of DD and DI genotype were significantly higher in ESRF patients thannormal control (DD: 15. 1 % VS6. 7 %,P<0. 01, DI: 54. 0%, VS 39. 7 %, P<0.05 ), whilethe frequency of II genotype was much lower in ESRF compared withnormal controls (30. 9% VS53. 6%, P<0. 01 ). Conclusion The DD and Dlgenotype of ACE gene are associated with the development of renalfailure and may be a risk marker for progression of renal diseases.