乳腺癌患者血清β_2-MG临床意义的评估

Study on expression and significance of serum β 2 Microglobulin to breast cancer

目的研究乳腺癌患者血清β２－ＭＧ表达的临床意义。方法采用放射免疫测定法检测血清β２－微球蛋白（Ｓβ２－ＭＧ）水平。结果乳腺癌６４例、乳腺炎病变４６例、乳腺良性肿瘤７２例及健康女性５２名，其β２－ＭＧ分别为４．３６±１．０９μｇ／ｍｌ、２．５３±０．４３μｇ／ｍｌ、２．４４±０．６２μｇ／ｍｌ及２．４１±０．３７μｇ／ｍｌ，乳腺癌患者组β２－ＭＧ水平明显高于其它组（Ｐ＜０．０１），同时β２－ＭＧ升高与乳腺癌的临床分期，病理分化程度及复发，转移等因素有明显相关性。结论β２－ＭＧ可作为乳腺癌辅助诊断及估计病情的血清学指标之一；术后随访检测，对疗效及预后的判定、辅助治疗的调整有一定的参考作用。

Objective To study on expression and significance of serum β 2 microglobulin (Sβ 2 MG) of breast cancer. Method: The serum β 2 microgbulin (Sβ 2 MG) levels were determined with the radioimmunoassay techniqe. Results: The Sβ 2 MG levels of patients with breast cancer (64), mastitis (46) and breast benign tumors (72), as well as normal women (52) were 4.36± 1.09 μg/ml,2.53±0.43μg/ml,2.44±0.62μg/ml and 2.41±0.37μg/ml respectively. These show that the Sβ 2 MG levels of breast cancer patients are much higher than the others (P<0.01), and we have found that the increase of Sβ 2 MG levels is related with the clinical stage, pathologic differentiation, recurrence and metastasis of breast cancer. Conclusion: It is suggested that the level of Sβ 2 MG may be considered as one of the serologic parameter in doagnosis and classfication of clinical stage of the breast cancer. Postoperative determination may be also used as a reference to estimate the therapeutic efffect and prognosis, and to revise the adjuvant treatment.