血清TC、ALB、PA和TBA测定在肝硬化中的临床意义

Clinical significance of serum total cholesterol,albumin,prealbum and total bile acid determination in paitients with liver cirrhosis

目的探讨血清总胆固醇(TC)、白蛋白(ALB)、前白蛋白(PA)和总胆汁酸(TBA)测定对肝硬化患者的早期诊断及疾病预后的临床应用价值。方法对临床确诊的肝硬化患者207例和健康对照组100例进行TC、ALB、PA、TBA检测。结果肝硬化组胆汁酸明显升高(P<0.01),而清蛋白、前清蛋白、胆固醇明显降低(P<0.01);随着肝功能减退,胆汁酸逐渐升高,而清蛋白、前清蛋白、胆固醇逐渐降低。且前清蛋白下降比清蛋白下降更早,阳性率更高。结论联合检测血清胆固醇、清蛋白、前清蛋白、胆汁酸对肝硬化患者肝功能评价及预后判断有重要意义。

Objective To study the clinical value of serum total cholesterol（TC）,albumin（ALB）,prealbumin（PA） and total bile acid（TBA） determination in patients with liver cirrhosis in early diagnosis and prognosis.Methods TC,ALB,PA,TBA were detected in 207 cases of liver cirrhosis with clinical diagnosis and healthy control group 100 cases.Results Liver cirrhosis group had significantly higher total bile acid （P〈0.01）,while albumin,prealbumin, total cholesterol decreased significantly（P〈0.01）;with liver dysfunction total bile acids gradually increased,while albumin,prealbumin,total cholesterol gradually decreased .And prealbumin fell down earlier than albumin ,the positive rate is higher.Conclusion Combined detection of serum total cholesterol, albumin, prealbumin and total bile acid is of great significance in the liver function evaluation and prognosis of patients with cirrhosis.