醋酸甲地孕酮预防放疗引起消化道反应的临床研究

Megestrol Acetate For Preventing Radiotherapy-induced Gastrointestinal Reactions:A Clinical Trial

目的观察醋酸甲地孕酮(MA)在预防腹部及盆腔放疗引起的消化道反应中的作用。方法收集2008年1月至2009年12月病理学和/或细胞学证实的消化道恶性肿瘤辅助性放疗60例,采用对照研究,随机分为A和B两组。A组辅助放疗期间及放疗后1周加用MA;B组给予单纯辅助性放射治疗,观察二组放疗引起的消化道反应的差异。结果放疗同时配合使用MA厌食、恶心、呕吐发生率下降(P<0.05);厌食、恶心、呕吐程度改善(P<0.001)。结论腹部及盆腔放疗同时配合使用MA可以改善患者的厌食、恶心、呕吐反应。

Objective To evaluate the effectiveness of megestrol acetate prevented radiotherapy-induced anorexia、nausea and vomiting.Methods Between June 2008 to December 2009 ,60 patients with abdominal cancer were randomly divided into two groups ：A and B.The patients in the A or B group respectively receive radiotherapy with or without megestrol acetate.Results Incidences of anorexia、 nausea and vomiting occurred less in patients who received megest rol acetate versus blank （P〈0. 05）.Patient s who received megestrol acetate had better improve anorexia、nausea and vomiting （P〈0. 001）.Conclusion Receiving megestrol acetate during radiotherapy can relieve digestive tract symptom.