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食管鳞癌组织中PTEN的表达及其临床意义 被引量：1

Expression of PTEN in esophageal squamous cell carcinoma ( ESCC) and its clinical significance
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摘要 目的观察PTEN在食管鳞癌组织当中的表达,探讨其与食管鳞癌发生的联系及其临床意义。方法应用免疫组化S-P法检测食管鳞癌组织、癌旁正常食管组织中PTEN的蛋白表达情况。结果 PTEN在正常食管黏膜和食管癌中阳性率分别为96.4%,65.5%。PTEN表达与食管癌的分化程度高低、浸润深度、是否有淋巴结转移和临床分期关系密切(P<0.05),与患者年龄、性别无关(P>0.05)。结论 PTEN蛋白异常表达在食管鳞癌发生发展过程中有重要作用。 Objective To investigate the protein expression and its significance of tumor suppressor gene PTEN in esophageal squamous cell carcinoma （ ESCC） . Methods Immunohistochemical staining S-P method was used to determine the expression of PTEN in ESCC and the normal esophageal tissues （ NET） which were adjacent to the carcinoma. Results The positive rate of expression of PTEN p rotein in NET and ESCC were 96.4% and 65.5%. Expression of PTEN in ESCC was related with expression of lymph node matastais , differention , TNM stage , tumor invasion （ P〈0. 05） , and no relationship with the patients’age and gender （ P〉0. 05）. Conclusion It is suggested that PTEN can be an objective marker for its pathological and biological behaviors of esophageal squamous cell carcinoma.
作者 黄绮国 倪仰鹏 陈蔓 谢丽霞
机构地区 揭阳市人民医院病理科
出处 《中国实用医药》 2010年第15期34-35,共2页 China Practical Medicine
关键词 食管鳞癌 PTEN 蛋白表达 Esophageal squamous cell carcinoma PTEN Protein expression
分类号 R735.1 [医药卫生—肿瘤]
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参考文献9

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同被引文献14

  • 1徐寿水,沈文律.转PTEN基因对人结肠癌细胞的抑制作用[J].肿瘤防治研究,2005,32(4):202-205. 被引量：4
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  • 7Alexiou GA ,Voulgaris S. The role of the PTEN gene in ma- lignant gliomas[ J]. Neurol Neurochir Po1,2010,44( 1 ) :80.
  • 8Zainuddin N, Jaafar H, Isa MN, et al. Malignant glioma: the involvement of loss of allelic heterozygosity and PTEN mu- tations in a group of Malay patients [ J ]. Southeast Asian J Trop Med Public Health ,2005,36( 3 ) :748.
  • 9Weng L,Brown J,Eng C. PTEN induced apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-depend- ent pathways [ J ]. Hum Mol Genet, 2001,10 ( 3 ) :237.
  • 10Koul D. PTEN signaling pathways in glioblastoma [ J ]. Cancer Biol Ther ,2008,7 (9) : 1321.

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中国实用医药
2010年 第15期

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