羟基喜树硷联合醛氢叶酸、5-氟脲嘧啶和/或顺铂治疗晚期卵巢癌36例的疗效观察

Clinlcal Research of HCPT in Combination with. LV+5Fu+/-DDP Regimen in treatment of advanced Ovarian Cancer

目的观察含羟基喜树硷(HCPT)联合化疗方案治疗晚期卵巢癌的近期疗效及不良反应。方法 29例,HCPT6mg/m2,静脉滴注,1～5月,醛氢叶酸100mg/m2。静脉滴注第1～5月;1-氟脲嘧啶400mg/m2,静滴第1～5月,顺铂(DDP)40mg,第1～3天,DDP应水化;7例因胃肠道反应未用DDP外余同上,3～4周为一个周期。结果 36例中总有效率(CR+PR)为50%(18/36)主要不良反应为血液学毒性,及恶心呕吐等。

Objective To observe the effeets and adverse reaction of regimen involved HCPT for patients with advanced ovarian cancer. Methods 29 cases of advanced ovarian cancer were treated with CF 100 mg/m^2 day1～5,5-Fluorouracil 400 mg/m^2 day1～5,HCPT 6 mg/m^2 day1～5,Cisplatin400 mg/m^2 day1～3. 7cases bssides DDP. other is same. Repeat every 3～4 weeks.Results Overall response rates （CR＋PR）were 50%,the major adverse raction are mild hematology toxicity. nausea and vomiting. Conclusion regimen involved HCPT is an effective and mild toxicity.Combined chemotherapy for advanced ovarian Cancer.