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移植自体骨髓间充质干细胞治疗急性心肌梗死 被引量：4

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摘要 目的探讨心内膜注射导管应用于干细胞移植治疗心肌梗死的可行性。方法将移植组和观察组分别经导管注射梗死心肌内移植体外扩增的自体骨髓间充质干细胞(mesenchymal stem cells,MSCs)和生理盐水,移植前后、6周及3个月超声评价左心功能。结果 MSCs移植数量平均为(3.81±0.09)×107个;左室射血分数正常对照组为(69.3±2.5)%,心肌梗死后降为(34.9±0.9)%,移植后3个月升至(61.9±1.8)%,超声提示室壁运动增强;与观察组相比,移植组左室收缩末压、左室舒张末压及左室压力最大上升/下降速率改善更明显(均为P<0.01)。结论进行自体骨髓干细胞经冠脉移植治疗冠心病、心肌梗死具有抑制左室重构、改善心脏功能的作用。
作者 商保军 白炎亮
机构地区 河南省人民医院血液病研究所
出处 《中国实用医药》 2010年第15期120-121,共2页 China Practical Medicine
关键词 骨髓移植 干细胞 心肌梗死 急性
分类号 R542.22 [医药卫生—心血管疾病]
  • 相关文献

参考文献10

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共引文献36

同被引文献51

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引证文献4

二级引证文献16

中国实用医药
2010年 第15期

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