ESWL后血清过氧化脂质、内皮素的变化及钙拮抗剂的防护研究

The changes of serum MDA and ET after ESWL and protective effect of calcium antagonist

将４０例行ＥＳＷＬ（体外冲击波碎石）的肾结石患者随机分为对照组，硝苯地平组，每组２０例，观察ＥＳＷＬ前后血清脂质过氧化物丙二醛（ＭＤＡ），内皮素（ＥＴ）的变化。结果：对照组ＥＳＷＬ后２ｈ血清ＭＤＡ、ＥＴ较ＥＳＷＬ前２ｈ均显著升高；硝苯地平组上述两种指标在ＥＳＷＬ后也有一定程度的升高，但与对照组相比有明显下降。提示：ＥＳＷＬ对肾脏的损伤可能与肾组织氧自由基及内皮素生成增多有关，钙拮抗剂硝苯地平可减少肾组织氧自由基及内皮素的产生，保护ＥＳＷＬ后的肾损害。

renal stone patients treated with ESWL were randomly divided into the control group and the nifedipine group. Serum MDA and ET were measured before and after ESWL. In the control group, a marked increase of serum MDA and ET was noted after EAWEL. While in the nifedipine group, there was a significant decrease of serum MDA and ET. Calcium antagonist nifedipine could decrease oxygen free radicals and ET, and protect the renal function from damage induced by ESWEL.