美沙酮维持治疗阿片类药物依赖者生命质量与抑郁状况的相关研究

The correlation study about quality of life and depression in opioid dependent patients receiving methadone maintenance treatment

目的探讨参加美沙酮维持治疗的阿片类药物依赖者的抑郁状况及其与患者生命质量的关系。方法使用贝克抑郁量表21项版（BDI-21）、药物成瘾者生命质量测定（QOL—DA）对120例美沙酮维持治疗门诊的阿片类药物依赖者进行横断面调查。结果≥41岁组患者生命质量的躯体功能维度分[（28．79±8．53）分]显著低于31～40岁组[（33．52±6．73）分]，差异具有显著性（P=0．003）。55％参加美沙酮维持治疗的阿片类药物依赖者BDI-21量表评分为中、重度抑郁。按BDI-21评分将患者分组为无抑郁、轻度抑郁、中度抑郁和重度抑郁组，其QOL-DA量表评分依次降低，差异有统计学意义（P〈0．01）。患者BDI-21量表总分与QOL—DA量表评分呈显著负相关，相关分析具有统计学意义（均P〈0．01）。结论参加美沙酮维持治疗的阿片类药物依赖者常合并抑郁并影响患者生命质量，需要对患者加强抑郁干预或治疗。

Objective To explore the depression status and its correlation with quality of life（QOL） in patients receiving methadone maintenance treatment（ MMT）. Methods 120 patients treated with MMT were assessed with Quality of Life Scale for Drug Addicts （QOL-DA） and Beck Depression Inventory （ BDI-21 ）. Results More than 41 years old group＇ s QOL-DA physical function domain （28.79 ± 8.53 ） was significantly lower than 31 N 40 years old group （33.52±6.73） （P= 0. 003）. According to BDI-21 score,55% patients receiving MMT were classified as moderate or severe depression. QOL-DA scores decreased in order of the depression severity classified as no depression group, mild depression group, moderate depression group and severe depression group according to the BDI-21 score,and the difference between the groups were significant statistically （P〈0. 01 ）. There was signif- icantly negative correlation between BDI-21 score and QOL-DA score （P〈 0.01 ）. Conclusion Depression is very common in opioid dependent patients receiving MMT and decreases their quality of life,so it is important to enhance depression intervention or treatment in MMT clinics.