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调节性B细胞与自身免疫性疾病 被引量：1

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摘要 以往认为，B淋巴细胞在自身免疫病中作为致病性淋巴细胞发挥作用。近年却发现，在自身免疫病小鼠模型中，采用B细胞清除疗法会加重疾病进程，提示B细胞具有免疫调节功能。调节性B细胞（Breg）是新近发现的一群新的B细胞亚群，它存在于B细胞多个亚型中。Breg通过刺激其表面分子，诱导释放调节性细胞因子如IL-10发挥调节作用。在不同自身免疫性疾病中，各种免疫细胞都可以成为Breg作用的靶细胞，表明Breg在自身免疫病复杂网络中的强大调节作用。
作者 汪路曼 储以微
机构地区 复旦大学上海医学院免疫学系
出处 《国际免疫学杂志》 CAS 北大核心 2010年第3期169-172,共4页 International Journal of Immunology
基金 基金项目：国家自然基金资助项目（30872378,J0730860）
关键词 调节性B细胞 自身免疫病 IL-10
分类号 R593 [医药卫生—内科学]
  • 相关文献

参考文献20

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共引文献2

同被引文献28

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引证文献1

国际免疫学杂志
2010年 第3期

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