抗原特异性T细胞受体基因转导技术优化策略的研究进展

Research on strategies of optimizing antigen-specific TCR gene transfer technology

肿瘤抗原特异性T细胞受体（TCR）基因转导技术作为肿瘤过继性免疫治疗的新手段之一，细胞和动物实验都证明它有很好的抗肿瘤作用，但临床试验结果却不尽人意。影响临床疗效主要原因是肿瘤抗原特异性T细胞受体不能有效地表达于T淋巴细胞表面，因而探索提高抗原特异性TCR高效表达的方法可能是解决这种问题的必要途径。

Redirecting T cell specificity by tumor antigen-specific T cell receptor（TCR） gene transfer, as one of new methods of tumor adoptive immunotherapy, has been proved that it has marked anti-tumor effect in vitro experiments and animal experiments. However, clinical trials were unsatisfactory due to ineffectively ex- pression of tumor antigen-specific TCR in T lymphocytes. Thus, exploring approach to improve the expression of antigen-specific TCR may be an essential way to solve this problem.