仙灵骨葆对卵巢大鼠骨密度和骨代谢的影响

Effect of Xianlinggubao on bone density and metabolism of ovariectomized rats

目的通过制造骨质疏松动物模型,研究去势大鼠骨密度和骨代谢指标的变化,为仙灵骨葆治疗骨质疏松症提供理论依据。方法将40只雌性SD大鼠随机分为4组,分别为:对照组、假手术组、仙灵骨葆小剂量组、仙灵骨葆大剂量组。手术摘除卵巢制造骨质疏松病理模型,待其恢复一W后,仙灵骨葆组每天按剂量灌胃给药60d,之后测定骨密度,并取血检测雌二醇(E2)、血钙(Ca)、血磷(P)。结果仙灵骨葆各剂量组骨密度和E2水平均高于对照组,差异具有统计学意义(P<0.05),而各组的Ca、P无明显差异,不具有统计学意义(P>0.05)。结论仙灵骨葆可提高去势大鼠骨密度和E2水平,具有有效治疗骨质疏松症的作用。

Objective To study bone density and metabolism of ovariectomized rats to provide theoretic foundation for Xianlinggubao treating osteoporosisMcthods 40 female SD rats were divided into four groups （ control group, false operation group, small and large dose group of xianlinggubao）. Osteoporosis model was made by ovariectomy. After giving Xianlinggubao 60 days, bone density, E2, Ca, and P were tested. Results Bone density and E2 level of small and large dosage of Xianlianggubao were higher than control group with statistic significance（ P 〈 0.05 ）. There was no difference on Ca and P between different groups without statistic significance （ P 〉 0.05 ）. Conclusion Xianlinggubao can increase bone density and E2 level of ovariectomy rats and has effect of treating osteoporosis.