国家一类抗肿瘤新药有机硒化合物乙烷硒啉的药效药理作用(英文)

Drug efficacy and pharmacological action of an organoselenium compound ethaselen,a novel antitumor drug

乙烷硒啉是由北京大学药学院设计合成并具有国际国内自主知识产权的有机硒化合物,其生物学靶点为硫氧还蛋白还原酶。作为国家一类抗肿瘤新药,乙烷硒啉正在进行临床Ⅰ期试验。本篇综述主要介绍目前已研究发表的乙烷硒啉的药效药理作用,包括体内体外的抗肿瘤作用及免疫调节功能。这些结果为乙烷硒啉进行更深入的抗癌临床研究提供了理论基础及治疗思路。

Ethaselen, an organoselenium compound designed and synthesized in the School of Pharmaceutical Sciences, Peking University, has been entitled to independent intellectual property rights both at home and abroad. As one of the novel antitumor drugs, ethaselen has been extensively studied in Phase I clinical trial, and its biological target is thioredoxin reductase. In this review, we focus on the ethaselen＇s efficacy and pharmacological actions, including antitumor effects both in vitro and in vivo, and immunologic functions. These research findings not only provide the theoretical basis for the anticancer study of ethaselen, but also guide the clinical trial of ethaselen.