原发性肝癌双介入化疗栓塞肝血流的测定

The Detection of Hepatic Blood Flow of both Interventional Embolization in Patients with Primary Hepatocellular Carcinoma

目的探讨肝动脉门静脉双介入化疗栓塞方法治疗原发性肝癌肝血流的变化。方法原发性肝癌50例分为肝动脉泵+门静脉泵灌注化疗(A组)25例,肝动脉泵化疗(B组)25例,观察彩超、增强CT、核素显像对原发性肝癌血流的变化。结果 A组92.0%高于B组84.0%(χ2=3.79,P<0.05);彩超发现肿块共56个,超声造影检出肿块54个,增强CT检出肿块55个。三者比较差异无统计学意义;术后门静脉血流量(1303.6±98.6)mL/min低于术前(1552.7±72.3)mL/min(t=2.345,P<0.05);术后脾静脉血流量(8073.8±30.6)mL/min高于术前(1055.9±29.8)mL/min(t=2.345,P<0.05);不同显像方法阳性率比较差异无显著性意义。结论肝动脉门静脉双介入化疗栓塞治疗原发性肝癌是安全有效的方法。

Objective To investigate the Hepatic blood flow of both interventional embolization in patients with primary hepatocellular carcinoma. Methods 50 cases of primary liver cancer were divided into the portal vein＋hepatic artery pump infusion pump（Group A）25 cases and hepatic artery pump chemotherapy （Group B）25 cases, The changes of blood flow in hepatocellular carcinoma were Observed by color Doppler ultrasound, enhanced CT, radionuclide imaging. Results The effective rate in Group A 92.0% were higher than the Group B 84.0%（χ^2=3.79, P〈0.05）; The tumor were find by Color Doppler ultrasound, ultrasound imaging and enhanced CT were 56, 54, 55 respectively. There were no significant difference; Portal venous flow （1303.6± 98.6）mL/min after treatment were lower than the preoperative （1552.7±72.3） mL/min （t=2.345, P〈0.05）; Splenic blood flow after treatment（4073.8±30.6）mL/min were higher than preoperative（1055.9±29.8）mL/min （t=2.345, P〈0.05）; The positive rates of different imaging methods were no difference significantly. Conclusion Hepatic artery and portal vein embolization pairs of interventional treatment of primary liver cancer is safe and effective method.