摘要
目的观察吉西他滨联合奈达铂治疗复发上皮性卵巢癌的近期疗效和毒副反应。方法吉西他滨1000mg/m2+生理盐水100mL,静脉滴注30min,d1和d8;奈达铂80mg/m2,静脉滴注2h;21d为1个周期。结果治疗30例复发上皮性卵巢癌,总有效率为63.3%,且毒副反应程度较轻,毒副反应主要为白细胞和血小板减少,但均为可逆,未出现因化疗毒性而死亡病例。结论吉西他滨联合奈达铂治疗复发上皮性卵巢癌是有效和安全的。
Objective To evaluate the short-term effect and side effects of Gemcitabine combined with Nedaplatin treating the patients with Recurrent ovarian cancer. Method Gemcitabine 1000mg/m2 for 1/2-hour infusion,dl and d8; Nedaplatin 80mg/m2 for 2-hour infusion, dl; Treatment was repeated Every 3 weeks. Result The overall response rate was 63.3% for 30 patients. The main side effects were marrow suppression including of leucopenia and thrombocytopenia, no patients dead for toxic reactions of chemotherapy. Conclusion Gemcitabine plus Nedaplatin is effective in patients with relapsed ovarian cancer. The adverse effects are tolerable.
出处
《中国医药指南》
2010年第14期14-15,共2页
Guide of China Medicine
关键词
卵巢癌
肿瘤复发
化学治疗
吉西他滨
奈达铂
Ovarian neoplasms
Neoplasm recurrence
Chemotherapy
Gemcitabine
Nedaplatin
