1996～2009年我院74例甲氨蝶呤致不良反应报告分析

Methotrexate-Induced ADRs in Our Hospital from 1996 to 2009: Analysis of 74 Cases

目的:了解甲氨蝶呤引起的不良反应,为深入开展药品不良反应监测工作提供依据。方法:对我院1996～2009年收集的74例甲氨蝶呤致不良反应报告进行回顾性分析。结果:74例不良反应中,男性46例,女性28例,平均年龄20.59岁。静脉滴注给药引发的不良反应为39例,占52.70%;鞘内注射引发的不良反应为25例,占33.78%。神经系统损害最为常见,主要为头痛、发热、下肢无力、脊髓神经根病变等。结论:临床应重视甲氨蝶呤引起的不良反应,须定期监测与报告,其可为临床治疗提供参考资料,减少或避免药品不良反应的发生。

OBJECTIVE： To investigate the adverse drug reactions （ ADRs） induced by methotrexate so as to provide references for ADR monitoring. METHODS： A total of 74 methotrexate-induced ADR reports collected from 1996 to 2009 in our hospital were analyzed retrospectively. RESULTS： The 74 ADR cases （46 males vs. 28 females） had a mean age of 20. 59 years,of which,39 cases （52. 70% ） were induced via drip infusion and 25 （33. 78% ） via intrathecal injection. The ADRs appeared maily as lesion of nervous system lesion including headache,fever, weakness of lower extremities and myeloradiculopathy etc. CONCLUSION： It is important to pay close attention to the ADR induced by methotrexate. Regular monitoring and reporting can provide important reference information for clinical treatment so as to lessen or avoid the occurrence of ADR.