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牙周组织自身稳定的分子机制研究进展 被引量：2

Research progress on homeostasis of periodontal tissues in molecular mechanism
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摘要 牙周膜相关蛋白(PLAP)-1为新确定的小分子富亮氨酸蛋白聚糖家族中的成员,是一种新的负性调节牙周膜矿化的因子,在牙周组织中特异性表达,在牙周组织动态平衡的自身稳定中起关键的作用。下面就PLAP-1的结构、组织分布和功能特点以及在牙周膜中的作用与调控机制等研究进展作一综述。 Periodontal ligament-associated protein（PLAP）-1 is a recently identified novel member of the small leucine-rich repeat proteoglycan family.PLAP-1 is expressed specifically and predominantly in the periodontal ligamen（tPDL）and that it negatively regulates the mineralization of PDL cells.PLAP-1 is thought to play a crucial role for homeostasis of periodontal tissues.Here we reviewed the structure,distribution,function and the regu-lation of the PLAP-1 in periodontal tissues.
作者 张盼盼 李纾
机构地区 山东大学口腔医院牙周科 山东省口腔生物医学重点实验室
出处 《国际口腔医学杂志》 CAS 2010年第3期291-293,297,共4页 International Journal of Stomatology
关键词 牙周膜 牙周膜相关蛋白 自身稳定 periodontal ligament periodontal ligament-associated protein homeostasis
分类号 R781.4 [医药卫生—口腔医学]
  • 相关文献

参考文献24

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共引文献22

同被引文献45

  • 1李纾,杨丕山,潘克清,谢瑞阅,段学静.富含亮氨酸的间质蛋白多糖在小鼠牙周组织发育中的组织学定位[J].中华口腔医学杂志,2005,40(6):485-488. 被引量：2
  • 2Bartold PM,Shi S,Gronthos S.Stem cells and periodontal regeneration.Periodontol 2000,2006,40(1):164-172.
  • 3Seo BM,Miura M,Gronthos S,et al.Investigation of multipotent postnatal stem cells from human periodontal ligament.Lancet,2004,364(9429):149-155.
  • 4Yoshizawa T,Takizawa F,Iizawa F,et al.Homeobox protein MSX2 acts as a molecular defense mechanism for preventing ossification in ligament fibroblasts.Mol Cell Biol,2004,24(8):3460-3472.
  • 5Duarte WR,Shibata T,Takenaga K,et al.S100A4:a novel negative regulator of mineralization and osteoblast differentiation.J Bone Miner Res,2003,18(3):493-501.
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  • 10Yamada S,Ozawa Y,Tomoeda M,et al.Regulation of PLAP-1 expression in periodontal ligament cells.J Dent Res,2006,85(5):447-451.

引证文献2

二级引证文献11

国际口腔医学杂志
2010年 第3期

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