细胞因子与肿瘤临床表现及转归的关系

Cytokines and their relationship to the symptoms and outcome of cancer

肿瘤组织中含有多种免疫细胞、致炎细胞因子和抗炎细胞因子，其相互作用可影响肿瘤的发生和发展，并且细胞因子可以预测肿瘤的预后。致炎细胞因子与疲劳、抑郁、认知障碍、厌食、恶液质、疼痛以及治疗引起的不良反应和耐药性有关，影响肿瘤患者的生活质量。

Cytokines can have either pro-or anti-inflammatory activity and immunosuppressive activity, depending on the microenvironment. Tumors contain immune cells and a network of pro-and anti-inflammatory cytokines, which collaborate in the development and progression of＇ cancer. Cytokine might prove to be prognostic. The systemic effects of pro- inflammatory cytokines are associated with fatigue, depression, cognitive impairment, anorexia, cachexia, pain, toxicity of treatment and resistance to treatment,which can affect quality of life.