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胶质瘤中微RNA研究进展 被引量：2

Advances in study of microRNAs in gliomas
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摘要 微RNA（microRNA，miR）可在转录后水平负调控靶基因表达，miR异常表达与肿瘤生成密切相关。对胶质瘤中多个miR异常表达及其机制的研究将对进一步探讨胶质瘤的分子病理及其诊治开拓新途径。 MicroRNAs（ miRNAs or miR）are a class of endogenous noncoding RNAs, average - 22 nt in length. MiRs negatively regulate gene expression at post-transcription level and the dysregulation of miRs is closely correlated with tumorigenesis. The present paper introduces the recent studies of aberration of miRs and its possible mechanisms in gliomagenesis,which will be helpful in further understanding the molecular pathology, developmemt of diagnostic biomarkers and new therapeutic strategies for gliomas.
作者 郝建伟(综述) 浦佩玉 张春智(审校)
机构地区 天津医科大学总医院神经外科天津市神经病学研究所神经肿瘤室
出处 《国际肿瘤学杂志》 CAS 2010年第3期200-203,共4页 Journal of International Oncology
基金 基金项目：国家自然科学基金资助项目（30872985、30981772）
关键词 微RNA 神经胶质瘤 MicroRNAs Glioma
分类号 R739.41 [医药卫生—肿瘤]
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参考文献27

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同被引文献15

  • 1Farias-Eisner G, Bank AM, Hwang BY, et al. Glioblastoma biomarkers from bench to bedside: advances and challenges. Br J Neurosurg, 2012, 26(2) : 189-194.
  • 2Vogazianou AP, Chan R, Ba cklund LM, et al. Distinct patterns of lp and 19q alterations identify subtypes of human gliomas that have different prognoses. Neuro Oncol, 2010,12 (7) :664-678.
  • 3Huse JT, Holland EC. Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma. Nat Rev Cancer, 2010, 10(5) :319-331.
  • 4Yan X, Ma L, Yi D, et al. A CD133related gene expression signature identifies an aggressive glioblastoma subtype with excessive mutations. Proc Natl Acad Sci USA, 2011,108 (4) :1591-1596.
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  • 6Srinivasan S, Patric IR, Somasundaram K, et al. A TenmicroRNA Expression Signature Predicts Survival in Glioblastoma. PLoS One, 2011,6(3) :e17438.
  • 7Ishizawa K, Komori T, Aihara Y, et al. Clear cells are associated with proliferative activity in ependymoma: a quantitative study. Clin Neuropathol, 2012,31 ( 3 ) : 146-151.
  • 8Motomura K, Natsume A, Watanabe R, et al. Immunohistochemical analysisbased proteomic subclassification of newly diagnosed glioblastomas. Cancer Sci, 2012,103 ( 10 ) : 1871-1879.
  • 9Jung CS, Foerch C, Schanzer A, et al. Serum GFAP is a diagnostic marker for glioblastoma multiforme. Brain, 2007 , 130( Pt 12) :3336-3341.
  • 10Lu KV, Jong KA, Rajasekaran AK, et al. Upregulation of tissue inhibitor of metalloproteinases (TIMP)2 promotes matrix metalloproteinase (MMP)2 activation and cell invasion in a human glioblastoma cell line. Lab Invest, 2004, 84( 1 ) :8-20.

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国际肿瘤学杂志
2010年 第3期

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