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乳腺癌分子遗传学研究进展

Advances in breast cancer molecular genetics
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摘要 乳腺癌易感基因的研究对有乳腺癌家族史的个体进行早诊和预防、阐明散发性乳腺癌发病机制、早诊、判断药物敏感性和预后、鉴别诊断良恶性疾病等均有重要意义。BRCA1和BRCA2是乳腺癌主要易感基因。其他易感基因诸如TP53能增加BRCA1、BRCA2的乳腺癌患病风险。 The study on susceptibility genes play an important role in early diagnosis and prevention for the individuals with family history of breast carcinoma, elucidation of pathologic mechanism of sporadic breast carcinoma, early diagnosis and adjudging prognosis, research on drug sensitivity, differential diagnosis of benign and malignant disease,etc. Two major susceptibility genes for breast cancer, BRCAI and BRCA2,are idenlified, respectively. Other tumor susceptibility genes such as TP53 are known to increase breast cancer risk of BRCA1 and BRCA2.
出处 《国际肿瘤学杂志》 CAS 2010年第3期207-210,共4页 Journal of International Oncology
基金 基金项目:浙江省医药卫生科技计划资助项目(2009A028)
关键词 乳腺肿瘤 基因 BRCA1 基因 BRCA2 Breast neoplasms Genes, BRCA1 Genes, BRCA2
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参考文献21

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