缺氧诱导因子-1在缺血性脑损伤中的作用

＇Ihe roles of hypoxia-indueible factor-1 in ischemic brain injury

作为低氧反应的核转录调节因子，缺氧诱导因子-1（hypoxia—inducible factor-1，HIF-1）在缺氧时表达上调，并通过与低氧反应元件结合，调控一系列下游靶基因，如血管内皮生长因子、葡萄糖转运体、红细胞生成素等的基因表达，在血管生成、无氧代谢以及细胞存活、增殖、迁移、分化等方面起着重要作用。文章对HIF-1的结构功能、活性调节及其在急性缺血性脑损伤中的作用进行综述。

Hypoxia-inducible factor-1 （H/F-1）, as a nuclear transcription regulator of the hypoxic response, is up-regulated during hypoxia, and it regulates a series of downstream target gene expression, such as vascular endothelial growth factor, glucose transporter and erythropoietin through binding with hypoxia response element. It plays important roles in angiogenesis, anerobic metabolism, cell survival, proliferation, migration, and differentiation. This article reviews the structure, function and activity regulation of HIF-1 and its roles in acute ischemic brain injury.