阿司匹林与低分子肝素治疗急性脑梗死的临床疗效对比

Comparison of Clinical Efficacy between Aspirin and Low Molecular Heparin in The Treatment of Acute Cerebral Infarction

目的:对比阿司匹林与低分子肝素治疗急性非心源性脑梗死的早期疗效和安全性。方法:选择180例首次非心源性急性脑梗死患者,随机分为阿司匹林治疗组和低分子肝素治疗组,分别在治疗前后进行临床疗效评定、神经功能缺损评分(NDS)及发生出血不良反应统计。结果:在急性非心源性脑梗死的早期治疗中,阿司匹林组与低分子肝素组临床疗效和神经功能缺损评分无统计学意义(P>0.05);但阿司匹林组无发生出血不良反应,低分子肝素组发生出血不良反应8例(8.89%),两组比较P<0.05,差异有统计学意义。结论:阿司匹林在急性非心源性脑梗死的早期治疗与低分子肝素疗效相当,但其不良反应轻,出血发生率低,而且使用方便、价格低廉,具有社会效益和经济效益。

Objective：To compare the early efficacy and safety of aspirin with those of low molecular heparin in treating the acute non-cardiac cerebral infarction.Methods：180 patients with the acute non-cardiac cerebral infarction were divided into aspirin group and low molecular heparin group at random.Evaluation of clinical efficacy,neurological deficit score （NDS） and statistics of bleeding of adverse reaction were respectively undergone before and after treatment.Results：Comparing the two groups in the early treatment of acute non-cardiac cerebral infarction,there was no statistical significance in clinical efficacy and NDS （P〉0.05）.No bleeding occurred in the aspirin group,while 8 patients （8.89%）had bleeding in the low molecular heparin group.There was statistical significance in comparing them （P〈0.05）.Conclusion：Aspirin has the same efficacy as that of low molecular heparin in the early treatment of acute non-cardiac cerebral infarction.But,little adverse reaction and low occurrence of bleeding can be found in using aspirin.Moreover,aspirin is inexpensive and easy to use.