消旋卡多曲、山莨菪碱、蒙脱石散联合治疗婴幼儿急性水样腹泻的临床研究

Combined Clinical Study of Acute Watery Diarrhea in Infants with Racecadotril、Anisodemine、Montmorillonite Powder

目的:探讨消旋卡多曲、山莨菪碱、蒙脱石散三药联用治疗婴幼儿急性水样腹泻的临床疗效及其安全性。方法:将符合条件的104例急性水样腹泻患儿随机分为治疗组和对照组,每组52例。两组病例常规治疗同,治疗组在此基础上加用消旋卡多曲、山莨菪碱、蒙脱石散剂三药口服,对照组仅加用蒙脱石散口服。观察两组的疗效及不良反应,比较两组的腹泻控制时间及总病程长短。结果:显效率:治疗组78.8%,对照组40.4%,x2=15.97,p<0.01;总有效率:治疗组94.2%,对照组67.7%,,x2=10.46,p<0.01;腹泻控制时间:治疗组3.23±2.34d,对照组5.21±2.19d,t=5.35,p<0.01;总病程:治疗组4.67±1.76d,对照组6.12±2.21d,t=3.68,p<0.01。说明治疗组的显效率、总有效率明显优于对照组(p<0.01),治疗组的腹泻控制时间、总病程明显短于对照组,差异极显著(p<0.01)。两组均未见严重不良反应。结论:消旋卡多曲、山莨菪碱、蒙脱石散治疗婴幼儿急性水样腹泻疗效显著,疗程短、见效快、简便安全、价格低廉、副作用小等特点,值得临床推广。

Objective：To study the effect and security of the racecadotril,Anisodemine and Montmorillonite Powder in the treatment of moderate or severe acute watery diarrhea in infants.Methods：A total of 104 infants with acute watery diarrhea enteritis were randomly divided into treatment group （n=52） and control group（n=52）.The same routine treatment was applied in both groups.Racecadotril,Anisodemine and Montmorillonite Powder were taken in treatment group,and only Montmorillonite Powder was given on the basis of routine treatment in control group.Then observe the curative and adverse effect of both groups,and compare the diarrhea controlling time and the diarrhea period of both groups.Results：explicit effective rate was 78.8% in the treatment group and 40.4% in control group,x^2=15.97,p〈0.01;total effective rate was 94.2% in treatment group and 67.7% in control group respectively;x^2=10.46,p0.01;the diarrhea controlling time：it was 3.23±2.34d in the treatment group,while it was 5.21±2.19d in the control group,t=5.35,p〈0.01;the diarrhea period;it was 4.67±1.76d in the treatment group and 6.12±2.21d in the control group,t=3.68,p〈0.01.It was revealed that the explicit effective rate and the total effective rate of the treatment group were distinctly higher than the control group,while the diarrhea controlling time and the diarrhea period of the treatment group were obviously shortened than the control group.There were significant difference between the two groups.（p〈0.01） and no side effect was found in the two groups.Conclusion：The curative effect of racecadotril granules,Anisodemine and Montmorillonite Powder for acute diarrhea in infants is cheap,significant and safe,with little adverse effects found.conclusion it can increase curative effect and shorten the length of the treatment.Therefore,it is worthwhile to spread such a kind of therapy in clinical use.