丙烯酰胺神经毒性机制研究概况

General survey of mechanisms of acrylamide neurotoxicity

丙烯酰胺(ACR)广泛存在于人们的生产生活环境中,研究表明暴露于丙烯酰胺可引起接触人群或动物产生神经毒性危害。近年来,大量研究致力于探讨丙烯酰胺的神经毒性机制,如加合物的形成、能量代谢异常、轴浆运输损伤、神经末梢损伤及凋亡等,但具体机制尚未阐明。本文对上述丙烯酰胺神经毒性的主要机制进行概述。

Acrylamide（ACR） is widespread in working and living environments.Neurotoxicities of persons and animals exposed to acrylamide were confirmed by former studies.Recently,the mechanisms of neurotoxicity induced by acrylamide,such as formation of adduct,abnormality of the energy metabolism,injury of the axoplasmic transport,and injury of the nerve terminal and apoptosis were more centered.In this review,its mechanisms were discussed.