青岛市成人双生子血脂相关指标的遗传度研究

Heritability analysis on serum lipids of adult twins in Qingdao City

目的了解成人双生子血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)的水平及其遗传度。方法选择青岛市双生子库中316对18到60岁的健康成人双生子,用自动生化分析仪检测其空腹血清TC、HDL-C、LDL-C、TG的浓度。鉴定卵性后,用Mx软件拟合遗传模型,调整性别、年龄后,计算血脂相关指标的遗传度。结果双生子空腹血清TC、HDL-C、LDL-C、TG水平的均值分别为(4.52±1.08)、(1.46±0.39)、(2.58±0.79)、(1.11±0.77)mmol/L。Mx软件拟合结构方程模型结果显示,TC、HDL-C和LDL-C三项指标的最适模型为AE模型,其遗传度依次为53%、62%和57%。TG的最适模型为CE模型,遗传度为0。结论遗传因素和环境因素对TC、HDL-C和LDL-C的浓度都有重要影响,而TG主要受到环境因素的影响。

Objective To study the level and heritability of serum total cholesterol（TC）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C） and triglycerides（TG） in adult twins sampled from Qingdao City of China.Methods 316 pairs of healthy twin aged 18 to 60 years were recruited from the database of Qingdao City twin registry.Fasting serum lipids were detected by automatic biochemical analyzer.The zygosity of twins was established by using polymorphic DNA-based microsatellite markers.The heritability was estimated by formulating univariate ACE twin mode in Mx soft.Results The average levels of fasting serum TC,HDL-C,LDL-C and TG were（4.52 ± 1.08）,（1.46 ± 0.39）,（2.58 ± 0.79） and（1.11 ± 0.77） mmol /L,respectively.The best fitting models adjusted by sex and age in Mx soft were AE model for TC,HDL-C and LDL-C,whereas CE model for TG.The heritability of TC,HDL-C,LDL-C and TG were 53%,62%,57% and 0,respectively.Conclusion It is considered that both genetic and environmental factors may influence the level of TC,HDL-C and LDL-C,whereas environmental effect may be the factor essential for the level of TG.