2002～2008年锦州市新生儿疾病筛查分析研究

Analysis and study of neonatal screening from 2002 to 2008 in Jinzhou

目的:探讨锦州市2002～2008年新生儿疾病筛查情况,总结经验,采取措施,促进筛查工作。方法:新生儿出生后72h,采足跟末稍血制成滤纸干血片,进行筛查。结果:2002～2008年锦州市新生儿筛查83328例,确诊先天性甲状腺功能减退症(CH)30例,CH发病率1/2777;苯丙酮尿症(PKU)为6例,PKU发病率为1/13888。新生儿筛查率呈逐年上升趋势,由2002年的26.6%上升至2008年的74.6%,平均每年以6.8%的速度上升。结论:锦州市CH及PKU发病率处于稳定水平,在进行新生儿疾病筛查工作中,完善新生儿疾病筛查管理办法和技术规范,加强社会宣传力度,重视筛查工作质量,对CH和PKU患儿早期治疗可避免体格和智能发育障碍,是提高人口素质的重要措施。

Objective：To explore the morbidity of Neonatal screening in Jinzhou from 2002 to 2008,to find better way to guide the future screening.Methods：A drop of plantar blood was obtained from newborns in 72 hours after delivery and screened.Results：Among 83 328 cases in Jinzhou from 2002 to 2008,30 cases were diagnosed CH,the morbidity rate of CH was 1/2 777,6 cases were diagnosed PKU,the morbidity rate of PKU was 1/13 888.The neonatal screening rate was increased from 27% in 2002 to 74.6% in 2008. The average yearly increasing speed was 6.8%.Conclusion：The morbidity rate of CH and PKU are stable in Jinzhou.The administration and issuing relevant regulation and technical criteria.The CH and PKU provide a possibility to avoid retardation of physical and mental development of the child ,so it is an effective measure to improve quality of the population.