高压氧辅助药物治疗一氧化碳中毒后迟发脑病的临床研究

Clinical study of hyperbaric oxygen combined with drugs on delayed encephalopathy after carbon monoxide poisoning

目的探讨药物和高压氧治疗急性一氧化碳中毒后迟发脑病的临床效果。方法将50例急性一氧化碳中毒后迟发脑病患者随机分为治疗组和对照组,治疗组给予烟酸、纳洛酮、脑活素及高压氧治疗,对照组给予高压氧治疗。结果治疗组25例痊愈16例,显效6例,进步2例,总有效率96%,无效1例,死亡0例。对照组25例痊愈9例,显效2例,进步2例,总有效率52%,无效10例,死亡2例。结论应用烟酸、纳洛酮、脑活素及高压氧治疗急性一氧化碳中毒后迟发脑病,可以提高救治成功率,降低致残率和病死率,是比较有效的治疗方案。

Objective It is to observe the clinical efficacy of drugs and hyperbaric oxygen on delayed encephalopathy after acute carbon monoxide poisoning.Methods 50 patients with delayed encephalopathy after acute carbon monoxide poisoning were randomly divided into control group that was treated with HBO and treatment group that was treated with nicotinic acid,naloxone,cerebrolysin and HBO.Results In treatment group,16 cases were recovery,6 cases were excellence,2 cases were advance,1 case was useless and no death case,and the total effective rate was 96%.In control group,9 cases were recovery,2 cases were excellence,2 cases were advance,10 cases were useless and 2 cases died,and the total effective rate was 52%.Conclusion Combined therapy of HBO and nicotinic acid,naloxone and cerebrolysin can elevate achievement ratio,decrease mutilation ratio and death rate on patients with delayed encephalopathy after acute carbon monoxide poisoning,and it is more effective therapeutic schedule.