N^2,N^2,N^6,N^6-四乙基-4-醛基吡啶-2,6-二甲酰胺的合成

Synthesis of N^2,N^2,N^6,N^6-tetraethyl-4-formylpyridine-2,6-dicarboxamide

以2,6-二甲基吡啶为原料,经KMnO4氧化、二乙胺酰胺化、吡啶环自由基亲核取代反应得到N2,N2,N6,N6-四乙基-4-羟甲基吡啶-2,6-二甲酰胺,然后用Sarret试剂氧化得到标题化合物并探讨了氧化反应的最佳条件,产物结构经1HNMR、IR和MS得到表征。该产物是合成新型吡啶类有机配体的重要中间体。

N^2,N^2,N^6,N^6-Tetraethyl-4-hydroxymethylpyridine-2,6-dicarboxamide was synthesized using 2,6-dimethylpyridine as the starting material via oxidation with KMnO4,amidation and free-radical substitution on pyridine ring.The final product was obtained by oxidation of N2,N2,N6,N6-tetraethyl-4-hydroxymethylpyridine-2,6-dicarboxamide with the Sarret reagent and the factors influencing the reaction were discussed.The structure of target product was characterized by 1HNMR,IR and MS.The target product is an important organic intermediate for the synthesis of novel ligands containing pyridine-2,6-dicarboxylic acid.