含双酰腙类新型席夫碱大环化合物的合成与表征

Synthesis and Characterization of Schiff Base Macrocyclic Compounds Containing Diacylhydrazone

报道以草酸、邻苯二胺为原料,合成中间体N,N′-双(2-苯氨基)-乙二酰胺(1),然后中间体(1)再与乙酰丙酮反应,合成得到了新型席夫碱大环化合物(2)。并探讨了合成目标大环化合物的最佳合成条件:以50%乙醇做溶剂,在高度稀释下中间体(1)与乙酰丙酮投料比(摩尔比)为1∶1,反应液pH值7~8,于75~80℃条件下反应18 h。目标大环化合物通过元素分析、1H NMR、IR、UV-vis和MS进行组成和结构表征。

Novel Schiff bases macrocyclic compounds containing diacylhydrazone（2） were synthesized from N,N-bis（2-aminophenyl）-oxalamide（1） and acetylacetone.The favorable reaction conditions of preparing the title macrocyclic compounds（2） were found as follows： the pH of reaction solution was from 7 to 8,the reaction time was about 18 h,the reaction temperature was 75～80 ℃,the mol ratio of N,N-bis（2-aminophenyl）-oxalamide（1） to acetylacetone was 1∶1,and the solvents was 50% ethanol.The novel Schiff base macrocyclic compounds（2） were characterized by elemental analysis,（）^（1）H NMR,IR,UVand MS.