β,β′-四亚甲基戊二酰亚胺的合成路线改进

Improved-synthesis Route of β,β′-Tetramethylene Glutarimide

在总结文献的基础上,对β,β′-四亚甲基戊二酰亚胺合成工艺进行了改进。以环戊酮为原料,首先反应得到中间体β,β′-四亚甲基戊二酸,并采用新的环合方法得到目标产物β,β′-四亚甲基戊二酰亚胺,总收率为62.8%。该方法反应条件温和,操作简便,适于工业化生产。

A novel synthesis route of β,β′-tetramethylene glutarimide was proposed.The title product was synthesized by a new method of cyclization,and the intermediate β,β′-tetramethylene glutaric was formed with cyclopentanone as the raw material.The total yield was 62.8%.This procedure has the advantages of mild reaction conditions,convenient operations and easier industrialization.