维生素D状态与心血管危险

Vitamin D Status and Cardiovascular Risk

已知维生素D最重要的功能是维持人体钙离子代谢的平衡。近些年来的研究发现维生素D受体广泛存在于人体的多种组织细胞中,因此维生素D是否还具有其他重要的生物学功能成为研究热点,其中维生素D缺乏与心血管风险的关系颇为引人注目。一些研究提示维生素D缺乏可能增加心血管风险,包括高血压、心力衰竭和缺血性心脏病等。但其致病机制和影响程度尚不十分明确。现综述了目前有关维生素D状态与心血管危险间关系的假设机制,并探讨为验证有关假设已进行的一些重要研究。

The most important function of vitamin D is known to maintain the balance of human calcium metabolism.Researches have found that vitamin D receptors present in a variety of tissue cells,thus whether vitamin D also has other important biological functions is of a hot topic in recent years,especially the relationship between a lack of vitamin D and cardiovascular risk.Some trials have shown that vitamin D deficiency may increase cardiovascular risk,including hypertension,heart failure and ischemic heart disease,et al.But the pathogenic mechanism and importance are not clear yet.This article summarizes the current hypothesis on the relationship between vitamin D status and cardiovascular risk,and some key researches that have been carried out to explore these hypothesis.