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冠心病调脂治疗新靶点相关进展 被引量：2

Progress of Research into Lipid Management of Coronary Heart Disease
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摘要 脂质代谢异常已成为冠心病发生发展的直接促进作用,而低密度脂蛋白胆固醇的水平增高一直被认为是冠心病发生发展的必要条件;随着研究进一步深入,其他脂蛋白及其组成成分载脂蛋白在动脉粥样硬化形成中也起着重要作用。运用一切干预手段,调整血浆中血脂各组份水平,特别是高密度脂蛋白和三酰甘油的调脂治疗,是目前调脂治疗发展新靶点的理论基础。 A clear association has been established between elevated serum cholesterol levels and increased the coronary heart disease.People think the elevated LDL-C is the most important factor in the coronary heart disease,But recent studies indicate that the LDL-C is not the only reason in the atherosclerosis.The development of atherosclerosis is also dependent upon the other factors：the TG and HDL-C.With all methods,adjust the serum cholesterol levels,for example：LDL-C,HDL-C and TG,thought to contribute to some of the beneficial effects of lipid-lowering in cardiovascular disease.This is the new to achieve target lipid goals now.
作者 热娜.热合木丁 马依彤
机构地区 新疆医科大学第一附属医院心脏中心
出处 《心血管病学进展》 CAS 2010年第3期468-471,共4页 Advances in Cardiovascular Diseases
基金 新疆自治区重大科技专项课题(200733146-3)
关键词 血脂 低密度脂蛋白胆固醇 高密度脂蛋白胆固醇 三酰甘油 lipid LDL-C HDL-C TG
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献20

  • 1The Scandinavian Simvastatin Survival Study Group.Randomized trial of lowering in 4 444 patients with coronary heart disease:the Scandinavian Simvastatin Survival Study(4S)[J].Lancet,1994,344:1383-1389.
  • 2Shepherd J,Cobbe SM,Ford I,et al.Prevention of coronary heart disease with pravastatin in men with hypercholeterolemia[J].N Engl J Med,1995,333:1301-1307.
  • 3Sacks FM,Pfeffer MA,Moye LA,et al.The effect of parvastatin on coronary events after myocardial infarction in patients with average cholesterol levels.Cholesterol and Recurrent Events Trial investigators[J].N Engl J Med,1996,335:1001-1009.
  • 4The Long-Term Interventing with Pravastatin in Ischaemic Disease(LIPID) study group.Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels[J].N Engl J Med,1998,339:1349-1357.
  • 5Downs JR,Clearfield M,Wies S,et al.Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels:results of AFCAPS/TexCaps:Air Force/Texas Coronary Atherosclerosis Prevention Study[J].JAMA,1998,299:1615-1621.
  • 6Lu ZL,Kou WR,Du PM,et al.Effect of xuezhikang,an extract from red yeast Chinese rice,on coronary events in a Chinese[J].中华心血管病杂志,2005,33:109-115.
  • 7Shah PK.High-density lipoprotein mimetic:focus on synthetic high-density lipoprotein[J].Am J Cardiol,2007,1001:n62-67.
  • 8叶平.以高密度脂蛋白为靶标的抗动脉粥样硬化治疗策略[J].中华心血管病杂志,2008,36(9):784-785. 被引量：5
  • 9Navab M,Anantharamaiah GM,Reddy ST,et al.An oral apoJ peptide renders HDL anti-inflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice[J].Arterioscler Thromb Vasc Biol,2005,25:1932-1936.
  • 10de Grooth GJ,Klerkx AH,Stroes ES,et al.A review of CETP and its relation to atherosclerosis[J].J Lipid Res,2004,45:1967-1973.

二级参考文献10

  • 1Barter PJ, Caulfield M, Eriksson M, et al. ILLUMINATE Investigators. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med, 2007, 357:2109-2122.
  • 2Kastelein JJP, van Leuven SI, Burgess L, et al. RADIANCE 1 Investigators. Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia. N Engl J Med, 2007, 356 : 1620- 1630.
  • 3Nissen SE, Tardif JC, Nicholls SJ, et al. ILLUSTRATE Investigators. Effect of torcetrapib on the progression of coronary atheroselerosis. N Engl J Meal,2007, 356:1304-1316.
  • 4Rader DJ. Illuminating HDL--is it still a viable therapeutic target? N Engl J Med, 2007, 357:2180-2183.
  • 5Tall AR. CETP inhibitors to increase HDL cholesterol levels. N Engl J Med, 2007, 356 : 1364-1366.
  • 6Kastelein JJ. Refocusing on use of cholesteryl ester transfer protein inhibitors. Am J Cardiol,2007,100 : n47-52.
  • 7Krishna R, Anderson MS, Bergman A J, et al. Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals : two double-blind, randomised placebo-controlled phase Ⅰ studies. Lancet, 2007, 370 : 1907-1914.
  • 8Shah PK. High-density lipoprotein mimeties: focus on synthetic high-density llpoprotein. Am J Cardiol, 2007,100 : n62-67.
  • 9Navab M, Anantharamaiah GM, Reddy ST, et al. An oral apoJ peptide renders HDL antiinflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol, 2005, 25 : 1932-1937.
  • 10Joy T, Hegele RA. Is raising HDL a futile strategy for atheroprotection? Nat Rev Drug Discov, 2008, 7:143-155.

共引文献4

同被引文献25

  • 1王璇,陆征丽,常红,刘莉,黄国伟.维生素C、E对体外血管内皮细胞氧化损伤保护作用的研究[J].天津医科大学学报,2005,11(2):187-189. 被引量：21
  • 2中国成人血脂异常防治指南[J].中华心血管病杂志,2007,35(5):390-419. 被引量：5223
  • 3Ross R. Atherosclerosis-an inflammatory disease[J].New England Journal of Medicine,1999,(02):115-126.
  • 4Tamiyama Y,Griendling KK. Reactive oxygen species in the vasculature moleculac and cellular mechanisns[J].Hypertension,2003,(06):1075.doi:10.1161/01.HYP.0000100443.09293.4F.
  • 5Yokoyama M. Oxidative stress and Atherosclerosis[J].Curr Opin Pharnacol,2004,(02):110-115.
  • 6Heistad DD. Endothelial function in the time of the giants[J].Journal of Cardiovascular Pharmacology and therapeutics,2008,(05):385-392.doi:10.1038/hdy.2009.25.
  • 7Takahashi H,Hara K. Cardiovascular disease and oxidative stress[J].Japanese Journal of Clinical Pathology,2003,(02):133-139.
  • 8Zittermann A. Vitamin D and disease prevention with special reference to cardiovascular disease[J].Prog Biophys Mel Biol,2006,(01):39-48.doi:10.1016/j.pbiomolbio.2006.02.001.
  • 9Autier P,Gandini S. Vitamin D supplementation and total mortaility:a mete analysis of randomized controlled trials[J].Archives of Internal Medicine,2007,(16):1730-1737.doi:10.1001/archinte.167.16.1730.
  • 10Hsu JJ,Tintut Y,Demer LL. Vitamin D and osteogenic differentiation in the artery wall[J].Clin J Am Soc Nephrol,2008,(05):1542-1547.

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心血管病学进展
2010年 第3期

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