膀胱癌CK20表达的临床应用

CK20 protein expression as significant prognostic factors in human bladder carcinoma

目的探讨CK20在膀胱癌中的表达与膀胱癌的侵袭、转移及预后的关系。方法用免疫组化SP法检测154例膀胱癌组织中CK20的表达。结果 CK20在103例肿瘤组织中有表达,阳性率为66.9%。CK20的表达和膀胱癌的T分期及远处转移呈正相关(P<0.05)。结论 CK20可能参与了膀胱癌的侵袭与转移,CK20可作为预后判断因子,结合病理分级和临床分期分析能提高对膀胱癌患者预后判断的准确性。

Objective This study was to investigate the correlations of CK20 expressions in tumor to metastasis, invasion, and prognosis of bladder cancer. Methods Expressions of CK20 in 154 specimens of bladder cancer were detected by Sp immunohistochemistry. Results Positive rate of CK20 was 66.9% in bladder cancer tissues. CK20 staining in cancer tissue was positively related with T stage and distant metastasis （P 〈 0.05 ） . Conclusion CK20 maybe participate in invasion and metastasis of bladder cancer. CK20 may be an prognostic factor and, when used in combination with pathologic grading and clinical staging, may increase accuracy of predicting prognosis of patients with bladder cancer.